Yes, this is possible. All scenes that can be executed manually, i.e. scenes that contain at least one actuator with a defined switching state, can be controlled via Alexa. The only exceptions are scenes that contain the SX5 DuoFern garage door opener. These are not executed via Alexa for security reasons.
Activate voice control for the scene and start the search via Alexa, either by clicking on Scenes in the HomePilot Skill and then on "Search", or by saying "Alexa, find my smart devices.".
To run the scene, say "Alexa, turn on
To operate devices together, the Alexa app also offers the possibility to create groups. These are independent of the groups and scenes created in HomePilot.